The National Football League regular season moves into week five as the various conferences and leagues begin to take shape. Followers have enjoyed many exciting games from the United States already this term, but we’re only getting started. There’s much more drama, excitement and shock results to come.
Matchday five from the NFL dominates the thinking of American Football lovers this week. The action begins at the So-Fi Stadium in Inglewood on Friday as the San Francisco 49ers play the Los Angeles Rams. Both teams enter with identical records, having won three games and lost one. Another victory would send one team a step closer to securing a playoff spot and football in the early stages of 2026.
Who will be the big winners this weekend? Gamblr offers all customers attractive betting odds and eye-catching specials on every match. Games broadcast live on TV attract the most markets and specials. Need a little help spotting a good bet. Our sportsbook gambling writer, Frank Monkhouse, offers his NFL preview and predictions.
Super Bowl 2026 outright odds
Before diving into the thick of this weekend’s NFL action and listing our best bets from round five, we’ll catch up on the Super Bowl betting.
Gamblr updates the outright odds after every round of fixtures, allowing bettors to track the price changes of their favourite teams. It also allows in-play bettors to wager following every result, seizing the best odds available.
NFL 2025/26 – Super Bowl 60 – Winner
Buffalo Bills @ 4.9
Philadelphia Eagles @ 7.2
Green Bay Packers @ 9.2
Detroit Lions @ 9.6
Baltimore Ravens @ 10.0
All teams and odds available on the Gamblr app and site.
San Francisco vs Los Angeles under 47 points @ 1.9
Our first bet of the weekend comes from SoFi Stadium in Inglewood, where the San Francisco 49ers play the Los Angeles Rams. Traders have the Rams as red-hot favourites in the pre-match betting, but will they live up to expectations and deliver an important victory?
The Rams start third in the NFC West after four games played. They enter with stats of three wins against one defeat, 2-0-0 at home and 1-1-0 on their travels. There’s little between the top three teams in the pool, with LA sitting on the heels of the San Francisco 49ers and the Seattle Seahawks. That means every score and win could be vital in securing the Rams’ place in knockout football.
San Francisco prepare for matchday five of the season, sitting proudly atop the NFC West, thanks to a 3-1-0 record. The numbers show they’ve scored 80 points in their previous four games, but have leaked 75, making them the lowest scorers of the group. Will they be out-muscled by an opponent that has scored 20 points more? The 49ers must meet fire with fire, while keeping things tight in defence.
I’m picking the Rams to win here and blow the division wide open at a crucial stage. They enter with a solid defence and will take advantage of an inconsistent and low-scoring opponent. The 49ers have the tools to cause an upset here, but they’ve blown hot and cold so far this season. Sticking hard to the stats makes sense. LA will stand firm at the back and have the quality to take their chances. Those after a better bet than you’ll find on the moneyline will enjoy the 1.9 offered by Gamblr on this match, producing less than 47 points.
Minnesota to beat Cleveland @ 1.5
The National Football League returns to the United Kingdom this weekend as the Minnesota Vikings play the Cleveland Browns in London. The stunning Tottenham Hotspur Stadium – home to English Premier League club Spurs – plays host. The venue will be packed to capacity, with millions more watching the play live on TV from 14:30 BST on Sunday. Which team will delight their UK fans?
Minnesota start third in the NFC North after four games played. They have won two games and lost a couple so far, with the split standing at 1-1-0 at home and 1-1-0 on the road. The Vikings have already scored 102 points, while conceding 80, giving them the best defence in the pool at this stage. Vikings have leaked eight points fewer than the pool leaders, the Detroit Lions. That shows there’s still all to play for in the NFC North.
The Cleveland Browns start rock bottom of the AFC North, with their stats stuck at one win against three defeats. That spare victory came at home, where they have a 1-1-0 record. The issues stem from their poor form on the road, as the Browns have lost both previous trips. Will that stretch to three this weekend in London? The pre-match betting odds available on the moneyline certainly suggest so.
The moneyline is the simplest way to bet on the NFL. Pick the team you expect to win, and if they deliver the goods, you’ll land the profits. It’s a 50/50 chance of making a profit, and you can bet as a single or add a few moneyline picks to your bet slip to create an accumulator. The Browns have real problems in offence, and I’m happy to oppose them until their numbers improve. The Browns have been far more consistent than their opponents, and that’ll make the difference in unfamiliar surroundings.
Dallas to beat New York @ 1.71
Our third and final pick of the weekend comes from the MetLife Stadium in East Rutherford. The betting pins Dallas as the most likely winner of this match, and I agree with that call.
We support a Cowboys win, taking as much confidence from New York’s problems as the Cowboys’ strengths. The Jets carry a woeful turnover margin, and their offence has offered little to suggest better times are ahead. They’re at the bottom of the AFC East, without a win in four, already conceding 120 points and scoring 90.
The Dallas Cowboys are far from perfect themselves and are suffering from injuries. But if they are anywhere near their best, our pick will defeat an opponent that’s getting increasingly desperate. I expect that first win to continue to elude New York.